The Monocyte Activation Test - A Pyrogentest Closer to Reality

     The Zwisler Lab is involved in the MATest since 2003 with the experiance of several thousend tested samples (Medical Devices and Pharmaceuticals).

     Over the years we used

several liters of human fresh blood,
about 40 different lots of cryoblood
and about 950 Test-Kits (IL1-b ELISA)
 

 

       

 

Since 2010 the MAT (Monocyte-Activation Test) is an official test of the European Pharmacopoeia (EP Chapter 2.6.30).

Parenteralia, medical devices, and biologically produced substances obtained from bacteria and other microorganisms may cause release of endogenous pyrogens (e.g., IL-1ß) if contaminated with exogenous pyrogens.

This pyrogenic contamination can be detected by the whole blood pyrogen test (In-vitro Pyrogen Test, IPT or  MAT), which is a two-part assay. It involves incubation of the sample with human blood, followed by an enzyme immunoassay for the measurement of e.g. IL-1ß.

 

FOR DETAILED INFORMATION, PLEASE CONTACT US ANY TIME

 

   IPT-Standard-Schema            MAT Standard     

schematic and measured endotoxine standard in the MAT

Shared Experience

MAT Vortrag Heidelberg        MAT Vortrag Frankfurt   Vortrag Heidelberg

                                                                 

MAT Vortrag PEI          MAT Vortrag Berlin